Factorial correspondence analysis (FCA) of peptide-binding affinity data for Class I molecules using 200,000 simulated 9-mer peptides. The first three correspondences were generated, representing about 50% of the total variance. Both HLA molecules and peptides are plotted, represented by red (HLA-A), blue (HLA-B), yellow (HLA-C) and grey (peptides), respectively. By default, no molecule is labeled. Alternatively, one can choose to label the 1st-field of all the "common" molecules, or to label only the molecules observed in a specific population with the size of each label proportional to the genetic frequency of it's corresponding allele. Moreover, it is also possibe to highlight the peptides with a specific amino acid residue at p2 or p9 positions.
How to Cite: Di D, Nunes JM, Jiang W, Sanchez-Mazas A. Like wings of a bird: functional divergence and complementarity between HLA-A and HLA-B molecules. Mol Biol Evol. 2021 Apr 13;38(4):1580-1594. doi: 10.1093/molbev/msaa325. PMID: 33320202.