Provides one and two-locus allele and haplotype frequencies as well as tests for Hardy-Weinber equilibrium, selective neutrality, global and individual linkage disequilibrium at multiple loci. It requires as input a valid UNIFORMAT file with loci data.
Note that if the sample size is limited or the data are too ambiguous, multiple solutions can occur during the frequency estimation. Under such conditions, the test for linkage disequilibrium cannot be performed and an error message is returned.
Filenames of type
Lab_Region_Population_2Locus.unif with loci separated by a tilda (
~) are expected (e.g.
AHPD-collection_SE-EUR_Slovenians_A~B~C~DRB1.unif) and input must be a valid UNIFORMAT file with